APS March 2023, Focus Session on "Intracellular transport"
Sorting category: #04.01.05
Where: Las Vegas, NV
When: March 5-10, 2023 (in person); March 20-22, 2023 (virtual)
Abstracts due: Oct 20, 2022
Invited Speaker: Melike Lakadyamali & Adriana Dawes
Co-organizers: Ajay Gopinathan and Elena Koslover
Intracellular transport of vesicles and organelles is typically carried out by a combination of diffusion and active transport that may rely on cytoplasmic flows or motor-driven transport along networks of actin and microtubule cytoskeletal filaments. Disruptions of transport can result in significant loss of cellular function and in disease at the organismal scale. While much work in the past has focused on the role of molecular motors in transport, there has been growing interest in how the architecture and organization of various cellular structures determine the distribution of cargo. Cytoskeletal features, such as the density, orientation, connectivity, post-translational modifications, and dynamics of filaments help guide and direct intracellular traffic. At the same time, the morphology of intracellular domains and flow patterns of cytoplasmic fluids contribute to transport organization within the cell. Insights into cell-scale transport regulation have been made possible by experimental advances that allow for the tracking of organelles and other cargo in vivo over extended periods of time and high-resolution imaging of the underlying cytoskeletal networks as well as theoretical efforts to account for the effects of cytoskeletal and cellular morphology and dynamics on transport. This focus session will bring together experimentalists and theorists working on these aspects of intracellular transport to highlight new emerging work, exchange ideas, seed new collaborations and create a strong community of researchers to drive the field forward.
Sorting category: #04.01.05
Where: Las Vegas, NV
When: March 5-10, 2023 (in person); March 20-22, 2023 (virtual)
Abstracts due: Oct 20, 2022
Invited Speaker: Melike Lakadyamali & Adriana Dawes
Co-organizers: Ajay Gopinathan and Elena Koslover
Intracellular transport of vesicles and organelles is typically carried out by a combination of diffusion and active transport that may rely on cytoplasmic flows or motor-driven transport along networks of actin and microtubule cytoskeletal filaments. Disruptions of transport can result in significant loss of cellular function and in disease at the organismal scale. While much work in the past has focused on the role of molecular motors in transport, there has been growing interest in how the architecture and organization of various cellular structures determine the distribution of cargo. Cytoskeletal features, such as the density, orientation, connectivity, post-translational modifications, and dynamics of filaments help guide and direct intracellular traffic. At the same time, the morphology of intracellular domains and flow patterns of cytoplasmic fluids contribute to transport organization within the cell. Insights into cell-scale transport regulation have been made possible by experimental advances that allow for the tracking of organelles and other cargo in vivo over extended periods of time and high-resolution imaging of the underlying cytoskeletal networks as well as theoretical efforts to account for the effects of cytoskeletal and cellular morphology and dynamics on transport. This focus session will bring together experimentalists and theorists working on these aspects of intracellular transport to highlight new emerging work, exchange ideas, seed new collaborations and create a strong community of researchers to drive the field forward.